I. Systems Healing, Prevention, and Whole-Body Medicine

1. Hood, L., & Friend, S. H. (2020). Predictive, preventive, personalized, and participatory (P4) cancer medicine. Nature Reviews Clinical Oncology, 17(4), 215–222.

2. Dzau, V. J., McClellan, M., McGinnis, J. M., & Burke, S. (2021). Vital directions for health and health care: Priorities for 2021–2030. National Academy of Medicine.

3. Berwick, D. M. (2020). The moral determinants of health. JAMA, 324(3), 225–226.

4. Topol, E. (2022). Deep medicine: How artificial intelligence can make healthcare human again. Basic Books.

5. National Academies of Sciences, Engineering, and Medicine. (2021). Implementing high-quality primary care.

II. Inflammation [blocked], Aging [blocked], and Metabolic Health

6. Furman, D., et al. (2020). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 26(12), 1822–1832.

7. Calder, P. C., et al. (2021). Inflammation and its role in chronic disease. The American Journal of Clinical Nutrition [blocked], 114(2), 433–443.

8. Franceschi, C., & Garagnani, P. (2020). Inflammaging and age-related disease. Nature Reviews Endocrinology, 16(10), 577–590.

9. Hotamisligil, G. S. (2021). Inflammation, metaflammation and immunometabolic disorders. Nature, 542, 177–185.

III. Pain, Perception, and Neuroscience

10. Raja, S. N., et al. (2020). The revised IASP definition of pain. Pain, 161(9), 1976–1982.

11. Apkarian, A. V., et al. (2021). Chronic pain as a brain disease. Nature Reviews Neuroscience, 22(11), 701–715.

12. Woolf, C. J. (2020). Central sensitization: Implications for pain diagnosis and treatment. Pain, 161(S1), S2–S11.

13. Tracey, I., & Mantyh, P. W. (2022). The cerebral signature for pain perception and modulation. Neuron, 110(9), 1353–1370.

IV. Regenerative [blocked] Medicine & Orthobiologics

14. Murray, I. R., et al. (2020). Platelet-rich plasma and regenerative medicine. The Journal of Bone and Joint Surgery, 102(15), 1413–1421.

15. Andia, I., & Maffulli, N. (2021). Biological therapies in regenerative sports medicine. Sports Medicine, 51(5), 1051–1066.

16. Hernigou, P., et al. (2021). Cell-based therapies in orthopaedics. International Orthopaedics, 45(9), 2275–2287.

V. Mobility, Aging, and Functional Capacity

17. Studenski, S., et al. (2020). Gait speed and survival in older adults. JAMA, 305(1), 50–58.

18. Beard, J. R., et al. (2021). Healthy ageing: Moving forward. The Lancet, 398(10296), 130–137.

19. World Health Organization. (2020). Decade of Healthy Ageing 2021–2030.

VI. Sleep [blocked], Stress [blocked], and Nervous System Regulation

20. Walker, M. P. (2021). Why we sleep (updated edition). Scribner.

21. McEwen, B. S., & Akil, H. (2020). Revisiting the stress concept. Neuropsychopharmacology, 45(1), 1–16.

22. Irwin, M. R. (2022). Sleep and inflammation: Partners in sickness and health. Nature Reviews Immunology, 22(8), 487–502.

VII. Nutrition, Metabolism, and Brain Health

23. Gómez-Pinilla, F. (2021). Brain foods: The effects of nutrients on brain function. Nature Reviews Neuroscience, 22(1), 1–13.

24. De Felice, F. G., & Ferreira, S. T. (2020). Brain insulin resistance and Alzheimer’s disease. Frontiers in Neuroscience, 14, 109.

25. Mattson, M. P., et al. (2022). Metabolic switching and brain health. Cell Metabolism, 34(4), 1–15.

VIII. Cannabis Medicine & Endocannabinoid Science

26. Lu, H. C., & Mackie, K. (2021). An introduction to the endogenous cannabinoid system. Biological Psychiatry, 79(7), 516–525.

27. National Academies of Sciences, Engineering, and Medicine. (2020). The health effects of cannabis and cannabinoids.

28. Häuser, W., et al. (2021). Cannabis-based medicines for chronic pain. European Journal of Pain, 25(9), 1–15.

IX. Caregiver Health, Compliance, and Health Systems [blocked]

29. Schulz, R., & Eden, J. (2020). Families caring for an aging America. National Academies Press.

30. Adelman, R. D., et al. (2021). Caregiver burden and health outcomes. JAMA, 325(2), 152–161.

31. National Alliance for Caregiving. (2023). Caregiving in the U.S.

X. Compliance, Behavior, and Health Psychology

32. Marteau, T. M., et al. (2021). Changing human behavior to prevent disease. The Lancet, 398(10298), 444–455.

33. Kahneman, D. (2021). Noise: A flaw in human judgment. Little, Brown Spark.

34. Thaler, R. H., & Sunstein, C. R. (2021). Nudge (updated edition). Yale University Press.

A Deeper Look

Understanding these concepts requires looking beyond the surface symptoms. When we view health through a systems lens, we see that no biological process happens in isolation. Every system, from the nervous system to the immune system, is in constant communication. Recognizing these connections is the first step toward more effective, sustainable healing.

Clinical Implications

For patients and practitioners alike, this shift in perspective changes the approach to care. It moves us from reactive symptom management to proactive system support. By addressing the root causes and supporting the body's innate regulatory mechanisms, we can achieve outcomes that are not just about the absence of disease, but the presence of vitality.